Investigating the impact of diabetes on depression and on the relationship
between depression and cognition 
   Lead Investigator:    Laili Soleimani
   Institution      :    Mount Sinai Hospital, Department of Psychiatry
   E-Mail           :    laili.soleimani@mssm.edu
   Proposal ID      :    614


   Publications:


1  Sano M, Zhu CW, Grossman H, Schimming C
   Longitudinal cognitive profiles in diabetes: Results from the National Alzheimer's Coordinating Center's Uniform Data
   Journal Article  J Am Geriatr Soc,65:2198-2204,2017,PMC5641239

   PUBLISHED





   Proposal Description:
   Introduction                                                                      Depression and dementia are both prevalent mental disorders in the aging          population. Although the epidemiological studies show the two conditions are      also interconnected, the biological correlates of this relationship remain        unclear.                                                                                                                                                            Recently, there has been growing body of literature on the association between    diabetes and dementia. Diabetes, and even pre-diabetic state, is associated       with an increased risk of cognitive decline including Mild Cognitive Impairment                                                                               (MCI) and dementia, i.e., Alzheimer???s disease (AD) and vascular dementia        (Cooper et al, 2015). Diabetes, also suggested by the epidemiological studies,    to be a risk factor for depression (Kessler et al., 2003, Anderson et al.,        2001). While the nature of the interaction between the diabetes and depression    is largely unknown, the comorbid depression in the diabetic patients largely      affects the clinical outcome as it is found to be associated with                 non-compliance with the medical treatment and worse psychosocial function         (Katon WJ, 2008). Depressed patients, who are also diabetic compared to the       non-diabetic depressed patients, are found to have higher depression scores and   report worse somatic well-being and contentment (Peterson et al, 2006).                                                                                             Investigating the inter-relationship of diabetes and depression, and              particularly in regard to the cognitive decline, can shed light on potential      common pathophysiology underlying these conditions. For example, given the high   risk of vascular abnormalities in diab